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PISA 2017 Preliminary Program

Monday September 25

7:45 AM

7:55 AM

Welcome
Satdarshan Paul S. Monga, University of Pittsburgh and Mark E. Sobel, ASIP

 

Tissue Microenvironment and Organ Pathobiology

Session 1
Barbarians at the Gate: Building a Different Kind of Wall  (Microbiome, Junctions, Injury and Infections)
Chairs: Richard Mitchell, Brigham & Women's Hospital and Kari Nejak-Bowen, University of Pittsburgh

7:55 AM

8:00 AM

Introduction
Kari Nejak-Bowen, University of Pittsburgh

8:00 AM

8:30 AM

Plasticity of the Mucosal Barrier: Insights into Regulation of Epithelial Repair
Asma Nusrat, University of Michigan

8:30 AM

9:00 AM

Oral Microbiome and Pulmonary Hypertension
Alison Morris, University of Pittsburgh

9:00 AM

9:30 AM

Understanding our Microbial Partners: Meta-omics and the Microbiome

Barbara Methe, University of Pittsburgh

9:30 AM

9:45 AM

Maternal Antibodies, the Neonatal Microbiota and Necrotizing Enterocolitis
Timothy Hand, University of Pittsburgh

9:45 AM

10:00 AM

Abstract-Driven Talk (ID6):
A Potential Broad-Spectrum Host-Targeting Antiviral Peptide Blocks Zika Virus Infection
Ronik Khachatoorian, University of California, Los Angeles

10:00 AM

10:25 AM

Coffee Break

Session 2
Inflammation, Resolution, and Wound Healing: Knitting the Raveled Sleeve of Care
Chairs: Richard Mitchell, Brigham & Women's Hospital and Cecelia Yates, University of Pittsburgh

10:25 AM

10:30 AM

Introduction
Richard Mitchell, Brigham & Women's Hospital

10:30 AM

11:00 AM

Biomaterials and their Grudging Acceptance by the Host
Edward Botchwey, Georgia Institute of Technology

11:00 AM

11:30 AM

How Injury Promotes Fibrosis and Cancer Development in the Liver
Robert Schwabe, Columbia University

11:30 AM

12:00 PM

AutoImmune Lung Fibrosis and Skin
Carol Bostwick, Medical University of South Carolina

12:00 PM

12:15 PM

More than Skin Deep: Understanding the Variables in Cutaneous Wound Healing
Cecelia Yates, University of Pittsburgh

12:15 PM

12:30 PM

Abstract-Driven Talk (IMIN18):
The Role of Vinculin In Neutrophil ß2 Integrin Adhesion and Motility

Zachary S. Wilson, Brown University

12:30 PM

1:25 PM

Lunch (Bridges Lounge)

Session 3
Cancer-associated Stroma and Tumor Immunology: Dismantling the Environmental Protection
Chairs: Satdarshan Paul S. Monga, University of Pittsburgh and Cecelia Yates, University of Pittsburgh

1:30 PM

1:35 PM

Introduction
Cecelia Yates, University of Pittsburgh

1:35 PM

2:05 PM

Regulatory T Cells
Dario Vignali, University of Pittsburgh

2:05 PM

2:35 PM

Tumor Microenvironment
Harold Dvorak, Beth Israel Deaconess Medical Center, Harvard Medical School

2:35 PM

3:05 PM

Next Target for Immune Checkpoint Blockade in Cancer
Hassane Zarour, University of Pittsburgh

3:05 PM

3:20 PM

Abstract-Driven Talk (L16):

Yuhua Xue, University of PittsburghGlypican-3 and CD81 Promote Development of Hepatocellular Carcinomas and Hepatoblastoma in Normal Hepatocytes and Liver Stem Cells through Negative Selection

 

Posters

3:30 PM

5:00 PM

View the Posters (Mezzanine Level)

  • Cancer - Mezzanine Lobby
  • Immunology and Inflammation - Panther Room
  • Infectious Disease and Neuropathology - Forbes Room
  • Kidney Pathobiology - Shadyside Room
  • Liver Pathobiology - Oakland Room
  • Pulmonary Pathobiology - Shadyside Room
  • Regenerative Medicine - Shadyside Room

ASIP Awards Presentation and Business Meeting

5:15 PM

 

 

9:00 PM

Gateway Clipper Dinner and Cruise (included)

Tuesday, September 26

Session 4
Premetastatic Niche and Regulation of Tumor Metastasis: Instituting a Travel Ban
Chairs: Piyali Dasgupta, Marshall University and Satdarshan Paul S. Monga, University of Pittsburgh

7:55 AM

8:00 AM

Introduction
Piyali Dasgupta, Marshall University

8:00 AM

8:30 AM

Exosomes and Microenvironment
Rama Khokha, University of Toronto

8:30 AM

9:00 AM

Exosomes in Tumor Progression and Treatment
Theresa Whiteside, University of Pittsburgh

9:00 AM

9:30 AM

Tumorigenesis, Metastasis, Wound Healing, Vascular Modeling - Liver (Organs) on Chip
Alan Wells, University of Pittsburgh

9:30 AM

9:45 AM

Abstract-Driven Talk (C15):

Anti-Metastatic Activity of Capsaicin in Human Lung Adenocarcinoma

Nicholas A. Nolan, Joan C. Edwards School of Medicine

9:45 AM

10:00 AM

Abstract-Driven Talk (C6):
Targeting Neuropilin-2 Prevents Pancreatic Ductal Adenocarcinoma Progression

Diane R. Bielenberg, Harvard Medical School, Boston Children’s Hospital

10:00 AM

10:25 AM

Coffee Break

 

Combating Diseases Through Improved Diagnostics and Therapeutics

Session 5
Cancer Epigenetics: Chromatin Landscape to Therapeutics
Chairs: Philip Iannaccone, Northwestern University and William B. Coleman, University of North Carolina at Chapel Hill

10:25 AM

10:30 AM

Introduction
Philip Iannaccone, Northwestern University

10:30 AM

11:00 AM

Histone Modifications in Cancer and Therapeutic Targeting of Histone Modifying Enzymes
Qin Yan, Yale University

11:00 AM

11:30 AM

The Cancer Methylome - Driver of Cancer Development and Target for Cancer Therapy
James Herman, University of Pittsburgh

11:30 AM

12:00 PM

Targeting the Epigenome in Cancer Therapeutics
Sara Sukumar, Johns Hopkins University

12:00 PM

12:15 PM

Decode mRNA Alternative Polyadenylation and Discover New Biology with cTag-PAPERCLIP
Hun-Way Hwang, University of Pittsburgh

12:15 PM

12:30 PM

Abstract-Driven Talk (C9):
Role of Polymorphonuclear Leukocytes in Inhibition of DNA Repair and Induction of Genomic Instability

Veronika Butin-Israeli, Northwestern University

12:30 PM

1:25 PM

Lunch (Bridges Lounge)

12:30 PM 1:25 PM LUNCH & LEARN WORKSHOP (Schenley Ballroom) - pre-registration required:
Science, Statistics and Getting it Right: An Interactive Discussion of Common Problems
Danny Milner, MD MSc(Epi) Chief Medical Officer American Society for Clinical Pathology
Sponsored by the ASIP Commitee for Career Development and Diversity and the ASIP Education Committee

Session 6
The Role of Biopsy in Precision Medicine: Making Diagnostics Great Again!
ChairsGregory Tsongalis, Dartmouth-Hitchcock Medical Center and William B. Coleman, University of North Carolina at Chapel Hill

1:25 PM

1:30 PM

Introduction
Gregory Tsongalis, Dartmouth-Hitchcock Medical Center

1:30 PM

2:00 PM

Adequacy of Cytology Specimens: FNA's and Smears for Interrogation of Genomic Variants
Helen Fernandes, Columbia University Medical Center

2:00 PM

2:30 PM

The ASO TAPUR Trial: A Molecular Driven Approach to Targeted Therapy
Richard L. Schilsky, University of Chicago

2:30 PM

3:00 PM

Cancer Genomics in the Era of Next-Generation Sequencing
Gregory Tsongalis, Dartmouth-Hitchcock Medical Center

3:00 PM

3:15 PM

Pancreatic Cancer
Aatur Singhi, University of Pittsburgh 

3:15 PM

3:30 PM

Abstract-Driven Talk:
Multiplexed Analysis of Myoepithelial and Immune Cell Biomarkers to Predict Progression of Ductal Carcinoma In Situ (C10)

Sonali Jindal, Oregon Health & Science University

Posters and Wine & Cheese Reception

3:45 PM

5:30 PM

View the Posters (Mezzanine Level)

  • Cancer - Mezzanine Lobby
  • Immunology and Inflammation - Panther Room
  • Infectious Disease and Neuropathology - Forbes Room
  • Kidney Pathobiology - Shadyside Room
  • Liver Pathobiology - Oakland Room
  • Pulmonary Pathobiology - Shadyside Room
  • Regenerative Medicine - Shadyside Room

 

Wednesday September 27

Session 7
Diagnostic Imaging Modalities: Incredible and Hugely Amazing
ChairsStanley Cohen, Rutgers-NJMS and Cecelia Yates, University of Pittsburgh

7:55 AM

8:10 AM

Introduction
Stanley Cohen, Rutgers - NJMS

8:10 AM

8:40 AM

The Silicon Assistant: Artificial Intelligence and Image Interpretation
Thomas Fuchs, Memorial Sloan Kettering Cancer Center

8:40 AM

9:10 AM

Breaking the Limits in Photoacoustic Imaging
Junjie Yao, Duke University

9:10 AM

9:40 AM

Translational Research in the Digital Dome
Yukako Yagi, Memorial Sloan Kettering Cancer Center

9:40 AM

9:55 AM

In Vivo and Ex Vivo Imaging Reveals a Role for Platelet Inflammasome in Sickle Cell Disease

Prithu Sundd, University of Pittsburgh

9:55 AM

10:25 AM

Coffee Break

 

Session 8
Signaling and Therapeutics: Targeting the Bad Hombres
ChairsWilliam B. Coleman, University of North Carolina at Chapel Hill and Satdarshan Paul S. Monga, University of Pittsburgh

10:25 AM

10:30 AM

Introduction
William B. Coleman, University of North Carolina at Chapel Hill

10:30 AM

11:00 AM

New Approaches to Therapy in Triple-Negative Breast Cancer
Brian Lehmann, Vanderbilt University

11:00 AM

11:30 AM

Targeting beta-catenin for Cancer
Marc Abrams, Dicerna Pharmaceuticals

11:30 AM

12:00 PM

Lung Cancer Epigenetics and Therapeutics
Malabika Sen, University of Pittsburgh

12:00 PM

12:15 PM

Beta-catenin Modulation in Cholestatic Liver Disease
Kari Nejak-Bowen, University of Pittsburgh

12:15 PM

12:30 PM

Abstract-Driven Talk (C26):
Synthesis of a Novel Non-Diuretic, Brain-Penetrating, Ethacrynic Acid Analog and Demonstration of its Potent Efficacy in Orthotopic Glioblastoma Models

Hanumantha Rao Madala, Texas Tech University Health Sciences Center

12:30 PM

Boxed Lunch and Farewell (included)